BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. This compound, derived from a partial sequence of human gastric juice protein, has a molecular weight of approximately 1,419.53 Da. BPC-157 has been the subject of extensive preclinical investigation spanning over two decades, with research applications centered on tissue repair mechanisms, gastrointestinal mucosal integrity, and cytoprotective signaling pathways.
In vitro studies suggest that BPC-157 modulates nitric oxide (NO) system activity and influences the FAK-paxillin signaling pathway, which plays a central role in cellular migration and adhesion. Preclinical models demonstrate accelerated granulation tissue formation and angiogenesis in tendon, ligament, and muscle explant cultures. Fibroblast proliferation assays have shown enhanced migration rates in the presence of BPC-157 at nanomolar concentrations, suggesting involvement of growth factor receptor transactivation. Additional cell culture work has identified interactions with the dopaminergic and serotonergic systems, indicating broader neuromodulatory research applications.
Gastrointestinal research represents a primary area of investigation. In mucosal cell models, BPC-157 has demonstrated cytoprotective effects against ethanol-induced and NSAID-induced cellular damage, with proposed mechanisms involving upregulation of EGF receptor expression and modulation of prostaglandin pathways. Studies in intestinal epithelial cell monolayers indicate promotion of tight junction protein expression, suggesting relevance to barrier function research.
Trimcore supplies BPC-157 as a lyophilized powder at ≥98% purity as determined by HPLC analysis. Each lot is accompanied by a Certificate of Analysis (CoA) documenting purity, peptide content, amino acid composition, and mass spectrometry confirmation. The compound is manufactured under strict quality control protocols to ensure batch-to-batch consistency suitable for reproducible experimental conditions.
For reconstitution, bacteriostatic water or sterile 0.9% sodium chloride solution is recommended. The lyophilized powder should be stored at -20°C for long-term preservation. Once reconstituted, solutions should be maintained at 2–8°C and utilized within 30 days. Repeated freeze-thaw cycles should be avoided to maintain peptide integrity. All handling should be conducted under aseptic conditions using appropriate laboratory protective equipment.
For research and laboratory use only. Not for human consumption.