CJC 1295 Without DAC + IPA

CJC-1295/Ipamorelin is a combination research preparation containing two complementary peptides: CJC-1295 (with Drug Affinity Complex) and Ipamorelin. CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 30 amino acids (modified GHRH(1-29)) with a molecular weight of approximately 3,367.97 Da. The Drug Affinity Complex (DAC) modification enables covalent binding to serum albumin, extending the compound’s half-life in preclinical models from minutes to days. Ipamorelin is a pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH₂ and a molecular weight of approximately 711.85 Da.

The mechanistic rationale for this combination lies in complementary receptor targeting. CJC-1295 acts through the GHRH receptor (GHRHR), a G-protein coupled receptor expressed on somatotroph cells, activating the cAMP/PKA signaling cascade. Ipamorelin selectively activates the growth hormone secretagogue receptor (GHS-R1a, ghrelin receptor) through a distinct signaling pathway. In pituitary cell culture models, concurrent activation of both receptor systems has demonstrated synergistic growth hormone release exceeding the sum of individual compound effects.

Preclinical studies have characterized the selectivity profile of Ipamorelin, noting minimal effects on ACTH, cortisol, or prolactin release in pituitary explant models—distinguishing it from earlier GH secretagogues such as GHRP-6. CJC-1295 with DAC has demonstrated sustained GHRHR activation in albumin-containing media systems, modeling the extended pharmacokinetic profile observed in preclinical research.

Research applications for this combination include GH axis physiology, somatotroph signaling crosstalk, receptor desensitization kinetics, and pulsatile hormone release modeling. The dual-receptor approach provides a valuable tool for distinguishing GHRH-dependent and ghrelin-dependence components of GH secretion in experimental systems.

TrimCore provides this combination as a lyophilized powder with each component at ≥98% purity by HPLC. Full Certificate of Analysis with identity and purity data for each peptide is included. Reconstitution in bacteriostatic water is recommended. Store lyophilized material at -20°C; reconstituted solutions at 2–8°C for up to 30 days.

For research and laboratory use only. Not for human consumption.