{"product_id":"sermorelin","title":"SERMORELIN","description":"\u003cp\u003eSemorelin Acetate is the acetate salt of a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). The amino acid sequence is Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂, with a molecular weight of approximately 3,357.9 Da. Semorelin retains full biological activity at the GHRH receptor (GHRHR), as the N-terminal 29 residues contain the complete receptor-binding and activation domain of the 44-amino acid native GHRH molecule.\u003c\/p\u003e\n\u003cp\u003eIn pituitary somatotroph cell cultures, Semorelin binds to GHRHR, a class B G-protein coupled receptor, activating the Gs\/adenylyl cyclase\/cAMP\/PKA signaling cascade. This leads to CREB phosphorylation and subsequent transcriptional activation of the GH-1 gene. Electrophysiological studies in pituitary cell preparations have demonstrated that Semorelin-induced cAMP elevation opens voltage-gated calcium channels, triggering GH vesicle exocytosis. Concentration-response studies indicate that Semorelin achieves maximal somatotroph stimulation with efficacy equivalent to full-length GHRH(1-44) in these model systems.\u003c\/p\u003e\n\u003cp\u003eSomatotroph axis research applications include investigation of GHRHR desensitization kinetics following sustained versus pulsatile compound exposure. In cell culture time-course experiments, Semorelin has been used to study receptor internalization, β-arrestin recruitment, and receptor recycling dynamics. Comparative studies with modified GHRH analogs (such as CJC-1295) enable investigation of structure-activity relationships governing GHRHR activation and the effects of enzymatic stability modifications.\u003c\/p\u003e\n\u003cp\u003eAdditional research applications include IGF-1 axis downstream signaling in hepatocyte models, where GH-stimulated JAK2\/STAT5 activation has been studied. In osteoblast cell cultures, Semorelin-stimulated GH release models have been used to examine effects on bone formation markers. Aging research utilizing senescent pituitary cell models has investigated age-related changes in GHRHR density and signaling efficiency.\u003c\/p\u003e\n\u003cp\u003eTrimcore peptide provides Semorelin Acetate as a lyophilized powder at ≥98% purity by HPLC with mass spectrometry identity confirmation. A comprehensive Certificate of Analysis accompanies each lot. Reconstitution in bacteriostatic water is recommended. Store lyophilized material at -20°C. Reconstituted solutions should be maintained at 2–8°C and utilized within 21 days. Standard aseptic peptide handling protocols are recommended.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research and laboratory use only. Not for human consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Trimcore Peptide Solution","offers":[{"title":"Default Title","offer_id":52908460015905,"sku":null,"price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/7122\/4353\/files\/IMG-6527.png?v=1782572857","url":"https:\/\/trimcorepeptide.com\/products\/sermorelin","provider":"Trimcore Peptide Solution","version":"1.0","type":"link"}