{"product_id":"cjc-1295-without-dac-ipa","title":"CJC 1295 Without DAC + IPA","description":"\u003cp\u003eCJC-1295\/Ipamorelin is a combination research preparation containing two complementary peptides: CJC-1295 (with Drug Affinity Complex) and Ipamorelin. CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 30 amino acids (modified GHRH(1-29)) with a molecular weight of approximately 3,367.97 Da. The Drug Affinity Complex (DAC) modification enables covalent binding to serum albumin, extending the compound’s half-life in preclinical models from minutes to days. Ipamorelin is a pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH₂ and a molecular weight of approximately 711.85 Da.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe mechanistic rationale for this combination lies in complementary receptor targeting. CJC-1295 acts through the GHRH receptor (GHRHR), a G-protein coupled receptor expressed on somatotroph cells, activating the cAMP\/PKA signaling cascade. Ipamorelin selectively activates the growth hormone secretagogue receptor (GHS-R1a, ghrelin receptor) through a distinct signaling pathway. In pituitary cell culture models, concurrent activation of both receptor systems has demonstrated synergistic growth hormone release exceeding the sum of individual compound effects.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003ePreclinical studies have characterized the selectivity profile of Ipamorelin, noting minimal effects on ACTH, cortisol, or prolactin release in pituitary explant models—distinguishing it from earlier GH secretagogues such as GHRP-6. CJC-1295 with DAC has demonstrated sustained GHRHR activation in albumin-containing media systems, modeling the extended pharmacokinetic profile observed in preclinical research.\u003c\/p\u003e\n\u003cp\u003eResearch applications for this combination include GH axis physiology, somatotroph signaling crosstalk, receptor desensitization kinetics, and pulsatile hormone release modeling. The dual-receptor approach provides a valuable tool for distinguishing GHRH-dependent and ghrelin-dependence components of GH secretion in experimental systems.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eTrimCore provides this combination as a lyophilized powder with each component at ≥98% purity by HPLC. Full Certificate of Analysis with identity and purity data for each peptide is included. Reconstitution in bacteriostatic water is recommended. Store lyophilized material at -20°C; reconstituted solutions at 2–8°C for up to 30 days.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor research and laboratory use only. Not for human consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Trimcore Peptide Solution","offers":[{"title":"Default Title","offer_id":52562142069025,"sku":null,"price":85.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/7122\/4353\/files\/BC76823F-E2F5-426F-AB1D-CAE8A7DD5E83.png?v=1776032575","url":"https:\/\/trimcorepeptide.com\/products\/cjc-1295-without-dac-ipa","provider":"Trimcore Peptide Solution","version":"1.0","type":"link"}